PROBLEM TO BE SOLVED: To provide an antigen-binding molecule that reduces the concentration of antigen in plasma. SOLUTION: For an antigen having two or more kinds of physiological activities in which it is difficult to inhibit the physiological activity with only one kind of antigen-binding molecule, the elimination of the physiological activity from the blood is promoted to reduce the physiological activity. Provide an antigen-binding molecule that can Furthermore, the present invention provides a method for producing the antigen-binding molecule, and a pharmaceutical composition containing the molecule as an active ingredient. [Selection diagram] None【課題】血漿中の抗原濃度を低下させる抗原結合分子の提供。【解決手段】一種類の抗原結合分子のみで生理活性の阻害が困難な，２種以上の生理活性を有する抗原に対し，血中からの消失を捉進する事で，その生理活性を低減させる事が可能な抗原結合分子を提供。更に該抗原結合分子の製造方法，及び当該分子を有効成分とする医薬組成物を提供。【選択図】なし
