Antigen-binding molecules that repeatedly bind to multiple molecules of antigen

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专利权人:

中外製薬株式会社

发明人:

井川 智之,石井 慎也,前田 敦彦,中井 貴士

申请号：

JP2015199906

公开号：

JP6082447B2

申请日:

2015.10.08

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/