HEINRICH-HEINE-UNIVERSITAET DUESSELDORF;KORTH, CARSTEN;KLINGENSTEIN, RALF;GMEINER, DR. PETER;LOEBER, STEFAN
发明人:
KORTH, CARSTEN,KLINGENSTEIN, RALF,GMEINER, DR. PETER,LOEBER, STEFAN
申请号：
ES06708555
公开号：
ES2445588T3
申请日:
2006.02.28
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compounds according to the general formula (1) as indicated below and / or their enantiomers, diastereomers as well as their pharmaceutically acceptable salts: ** Formula ** in which: A is a six-membered ring, unsaturated or partially saturated； Q1, Q2, Q3, Q4 are selected in each case independently from each other from the group comprising CH, Chalogen, C-O-C 1 -C 10 alkyl, C-CF3, C-CN and / or CH2； R1, R2, R3, R4, R5, R6 are independently selected from each other from the group comprising H, halogen, C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkynyl, C1-C10 alkyloxy, CF3, NH2 , NHR9, the R9 moiety being selected from the group comprising C1-C10 alkyl and / or C1-C10 acyl, NO2 and / or CN； X1, X2 are in each case H, or X1 and X2 together form X, where: X is selected from the group comprising CH2, CH2-CH2, CH>； = CH and / or O； Y1, Y2 are in each case independently of each other C1-C10 unbranched or branched alkyl； Z is a structural element Z1 or Z2 as indicated below, where: Z1 has the following general formula (2): ** Formula ** in which: m is 1, 2, 3, 4, 5 or 6, R7 , R8 are independently selected from each other from the group comprising H, C1-C10 alkyl, forming R7 and R8 if necessary through a CH2-CH2 group a ring, and / or C1-C10 acyl； Z2 presents the following general formula (3): ** Formula **Compuestos de acuerdo con la fórmula general (1) tal como se indica a continuación y/o sus enantiómeros,diastereómeros así como sus sales farmacéuticamente aceptables:**Fórmula** en la que: A es un anillo de seis miembros, insaturado o parcialmente saturado； Q1, Q2, Q3, Q4 se seleccionan en cada caso independientemente entre sí del grupo que comprende CH, Chalógeno, C-O-alquilo (C1-C10), C-CF3, C-CN y/o CH2； R1, R2, R3, R4, R5, R6 se seleccionan en cada caso independientemente entre sí del grupo que comprende H,halógeno, alquilo C1-C10, alquenilo C1-C10, alquinilo C1-C10, alquiloxilo C1-C10, CF3, NH2, NHR9, seleccionándoseel resto R9 del grupo que comprende alquilo C1-C10 y
