具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物农业专利-农业专业知识服务系统

发明人:: MADDAFORD, SHAWN,史恩　玛达佛,史恩　瑪達佛,RAMNAUTH, JAILALL,杰罗　瑞姆挪斯,傑羅　瑞姆挪斯,RAKHIT, SUMAN,苏曼　拉克希,蘇曼　拉克希,PATMAN, JOANNE,琼安　派特曼,瓊安　派特曼,ANNEDI, SUBHASH C.,苏哈希　安呢迪,蘇哈希　安呢迪,ANDREWS, JOHN,约翰　安德鲁斯,約翰　安德魯斯,DOVE, PETER,彼,史恩玛达佛,史恩瑪達佛,杰罗瑞姆挪斯,傑羅瑞姆挪斯,苏曼拉克希,蘇曼拉克希,琼安派特曼,瓊安派特曼,苏哈希安呢迪,蘇哈希安呢迪,约翰安德鲁斯,約翰安德魯斯

摘要：: The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.本發明提供喹諾酮、四氫喹啉及其相關化合物，其抑制一氧化氮合成酶(NOS)，尤其相較於其他NOS同功異構物，可選擇性抑制神經元性一氧化氮合成酶(nNOS)。本發明之NOS抑制劑，當單獨或與其他醫藥上的活性試劑結合，可用於治療或預防各種醫學症狀。