The present invention relates to compounds and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.本發明係關於會抑制Hsp90之活性的化合物與組成物。本發明進一步係關於在需要抑制Hsp90之活性的個體中抑制Hsp90之活性之方法,以及用於在需要預防或治療過度增生性失調(例如癌症)的個體中預防或治療過度增生性失調的方法,其包括將本發明的化合物、或包括如此化合物的組成物投藥至該個體。