A catheter procedure system includes a controller programmed to advance the guide wire through a path using a guide wire advance/retract actuator, determine if a guide wire is in a desired path based at least on at least one image of a region of interest, rotate the guide wire using a guide wire rotate actuator if the guide wire is not in the desired path, wherein the guide wire is rotated a predetermined amount, and retract the guide wire using the guide wire advance/retract actuator. The steps of advancing the guide wire and retracting and rotating the guide wire using guide wire advance/retract actuator and the guide wire rotate actuator are repeated until the guide wire is in the desired path. The guide wire is advanced to a desired position using the guide wire advance/retract actuator.
