A system and method for enhanced navigation for use during a surgical procedure including planning a navigation path to a target using a first data set of computed tomography images previously acquired； navigating a marker placement device to the target using the navigation path； placing a plurality of markers in tissue proximate the target； acquiring a second data set of computed tomography images including the plurality of markers； planning a second navigation path to a second target using the second data set of computed tomography images； navigating a medical instrument to a second target； capturing fluoroscopic data of tissue proximate the target； and registering the fluoroscopic data to the second data set of computed tomography images based on marker position and orientation within the real-time fluoroscopic data and the second data set of computed tomography images.
