Eric M. Pridgen,Frank Alexis,Omid C. Farokhzad,Robert S. Langer,Richard S. Blumberg
申请号：
US15692116
公开号：
US20180021455A1
申请日:
2017.08.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to be delivered, where the receptor mediates transcytosis of the nanoparticle into and through the cells. In a preferred embodiment, the targeting moiety is the neonatal Fc receptor. Examples demonstrate Fc-targeted nanoparticles which are actively transported across the intestinal epithelium, providing a route for the oral delivery of nanoparticle encapsulated active agents including peptides such as insulin.
