Disclosed herein is a recombinant polypeptide comprising two single chain Fc domains fused or covalently attached to each other by a peptide linker, with the proviso that the peptide linker does not comprise an antibody hinge domain (also referred to herein as an “sc(Fc)2 construct”). In a further aspect, the recombinant polypeptide also comprises, or alternatively consists essentially of, or yet further consists of a first therapeutic moiety. Methods for use of the polypeptides, as well as methods for making same, are provided herein.
