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Methods to reprogram splice site selection in pre-messenger RNAs
专利权人:
Faiz-ul Hassan Nasim;Jonathan Villemaire;Sherif Abou Elela;Benoit Chabot
发明人:
Benoit Chabot,Jonathan Villemaire,Sherif Abou Elela,Faiz-ul Hassan Nasim
申请号:
US12291887
公开号:
US08546346B2
申请日:
2008.11.14
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to a method of modulating splice site selection, splicing and alternative, the method comprising the step of hybridizing an oligonucleotide-protein conjugate to a target pre-mRNA molecule in a cell or cell extract, wherein the oligonucleotide-protein conjugate comprises an oligonucleotide moiety which comprises at least two distinct sequence elements: (i) a nucleic acid sequence that is complementary to a specific region upstream of the splice site in the target pre-mRNA molecule; and (ii) an extension containing a protein binding site sequence element for covalently binding a protein; wherein the protein moiety comprises a protein capable of modulating splicing of the splice site upon binding with the protein binding site.
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