AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NANYANG TECHNOLOGICAL UNIVERSITY
发明人:
LUO, Dahai,FINK, Katja,YONG, Hui Yee,HO, Chin Yong Victor
申请号：
SG11202006396S
公开号：
SG11202006396SA
申请日:
2019.01.17
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, said RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.
