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PYRAZOLYLBENZO(D)IMIDAZOLE DERIVATIVES
专利权人:
CELON PHARMA S.A.
发明人:
ZDZALIK Daria,ZDZALIK Daria,LIPNER Joanna,LIPNER Joanna,WIECZOREK Maciej,WIECZOREK Maciej,DZWONEK Karolina,DZWONEK Karolina,YAMANI Abdellah,YAMANI Abdellah,DUBIEL Krzysztof,DUBIEL Krzysztof,LAMPARSKA-
申请号:
SI201430168
公开号:
SI2970210T1
申请日:
2014.03.07
申请国别(地区):
SI
年份:
2017
代理人:
摘要:
A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively R1 represents &mdashX-Q-P, wherein X is absent or represents &mdashCH2&mdash, &mdashC(O)&mdash, or &mdashC(O)NH&mdash(CH2)k&mdash, wherein k is 0, 1 or 2 Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5 P is absent or represents straight- or branched-chain C1-C3 alkyl, &mdash(CH2)l&mdashNR2R3, or &mdash(CH2)m&mdashC(O)&mdashNR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, &mdashNH&mdashor &mdashN(C1-C2)alkyl- and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)
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