ZDZALIK DARIA,LIPNER JOANNA,WIECZOREK MACIEJ,DZWONEK KAROLINA,YAMANI ABDELLAH,DUBIEL KRZYSZTOF,LAMPARSKA-PRZYBYSZ MONIKA,GRYGIELEWICZ PAULINA,STANCZAK ALEKSANDRA
申请号：
IN3347/KOLNP/2015
公开号：
IN2015KN03347A
申请日:
2015.10.12
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
A compound represented by the general Formula (I), whereinhydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively R1 represents -X-Q-P, wherein X is absent or represents –CH2-, –C(O)-, or –C(O)NH-(CH2)k-, wherein k is 0, 1 or 2 Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5 P is absent or represents straight-or branched-chain C1-C3 alkyl, –(CH2)l-NR2R3, or–(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absentand R2and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6- membered saturated heterocyclicring, wherein one of carbon atoms can be replaced with oxygen, -NH-or –N(C1-C2)alkyl- and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)
