KIM, Hyeon Jin,김현진,HONG, Seong Tshool,홍성출,CHUNG, Hea Jong,정혜종,JOO, Min Kyu,주민규,CHO, Hea Guk,조해국,HONG, Jinny,홍유진
申请号：
KRKR2013/004297
公开号：
WO2014/178468A1
申请日:
2013.05.15
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention relates to anticancer nanoparticles with improved target specificity for cancer tissue, and a preparation method therefor, and more specifically, to anticancer nanoparticles with amplified target specificity, wherein an anticancer drug, serum albumin as a nanoparticle base material, and a porphyrin-based compound as a target specific material are noncovalently bonded, and a preparation method therefor. The anticancer drug, the serum albumin as a base material, and the porphyrin as a target specific material are noncovalently bonded in the anticancer nanoparticles with amplified target specificity according to the present invention, and thus it is possible to prevent a toxic side effect, a decrease in efficacy of the anticancer drug and a decrease in target specificity, which frequently appear in anticancer nanoparticles, the nanoparticles are further stabilized, and cancer target specificity is amplified during electromagnetic wave irradiation since an active oxygen-forming function, which is an intrinsic function of porphyrin, is active due to no change to the chemical structure of porphyrin, which is a target specific material. The effects work in multiple ways, thereby maximizing tumor transfer/targeting efficiency of the anticancer drug in the anticancer nanoparticles with amplified target specificity of the present invention, and thus it is possible to expect effective treatment in both early and terminal stage cancer.La présente invention concerne des nanoparticules anticancéreuses présentant une spécificité améliorée de cible pour le tissu cancéreux, et son procédé de préparation, et plus spécifiquement, des nanoparticules anticancéreuses présentant une spécificité amplifiée de cible, dans lesquelles un médicament anticancéreux, de lalbumine sérique comme matériau de base sous forme de nanoparticules, et un composé à base de porphyrine comme matériau spécifique de cible ne sont pas liés de manière covalente, et leur procédé de préparatio
