The present invention concerns a compound selected from triptolide, derivatives thereof, and pharmaceutically acceptable salts of triptolide and derivatives thereof, or a composition comprising such a compound for use in the topical treatment and/or prevention of a tumor or precancerous pathology of the skin.本發明有關於一種選自於雷公藤內酯、其衍生物,及雷公藤內酯與其衍生物的藥學上可接受之鹽類的化合物,或是一種包含此一化合物的組成物之用途,係用於局部治療及/或預防皮膚之腫瘤或癌前病理。