The present invention is directed to a compound of formula (I) for use in a method to treat or ameliorate amyloid or tau pathologies, such as Alzheimer’s disease, or symptoms thereof. The invention is also directed to new compounds of formula (I), of subformula (II), (III), (IV), or (V).本發明係關於一種用於治療或改善澱粉樣蛋白或τ病理狀態(諸如阿茲海默症或其症狀)之方法中的式(I)化合物。本發明也關於式(I)、子式(II)、(III)、(IV)、或(V)之新化合物。