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Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
专利权人:
Karus Therapeutics Limited
发明人:
Shuttleworth, Stephen Joseph,Cecil, Alexander Richard Liam,Hill, Thomas James,Silva, Franck Alexandre
申请号:
AU2010286168
公开号:
AU2010286168A1
申请日:
2010.08.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N-H, N-(C-Calkyl) or S; each X is independently CH or N; R is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R is (LQ)Y; and each R is independently H, C-C alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.
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