"compound, use of a compound, method for treating a condition or disorder, method for mitigating renal damage, pharmaceutical formulation, and process for preparing a compound"
Christine Mary Richardson,Giles Abert Brown,Jonathan Stephen Mason,Miles Stuart Congreve,Stephen Philippe Andrews
申请号：
BR112012019540
公开号：
BR112012019540A2
申请日:
2011.02.07
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
compound, use of a compound, method for treating a condition or disorder, method for mitigating renal damage, pharmaceutical formulation, and process for preparing a compound. According to the invention there is provided a compound of formula a1 which may be useful in treating an improved condition or disorder (o) by inhibiting the α1-a2b receptors or, particularly, a2a wherein the compound of formula a1 has the structure, wherein a represents cy1 or heta； cy1 represents a fully saturated or partially unsaturated 5- to 14-membered aromatic carbocyclic ring system comprising one, two or three rings, which cy1 group is optionally substituted by one or more substituents r4； heta represents a 5- to 14-membered heterocyclic group which may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from the o, sen heterocyclic group which may comprise one, two or three rings and this heta group which is optionally substituted by one or more substituents r4b； b represents a cy 2 or hetb； cy 2 represents a fully saturated or partially unsaturated aromatic 3-10 membered carbocyclic ring system comprising one or two rings, which cy 2 group is optionally substituted by one or more substituents r 4c； hetb represents a 3- to 10-membered heterocyclic group which may be aromatic, fully saturated or partially unsaturated, and which contains one or more heteroatoms selected from o, sen, which heterocyclic group may comprise one or two rings and this hetb group which is optionally substituted by one or more substituents r4d.composto, uso de um composto, método para tratamento de uma condição ou um distúrbio, método para mitigar dano renal, formulação farmacêutica, e, processo para a preparação de um composto. de acordo com a invenção é fornecido um composto da fórmula a1 que pode ser útil no tratamento de uma condição ou um distúrbio melhorada(o) pela inibição dos receptores a1-a2b ou, particularmente, ao a2a em que o composto da formul
