NANJING ZHONGRUI MEDICINE CO., LTD;JIANGSU KEFEIPING MEDICINE CO., LTD;SU, GUOQIANG
发明人:
SU, GUOQIANG
申请号：
WO2008CN70118
公开号：
WO2009036656(A1)
申请日:
2008.01.16
申请国别(地区):
世界知识产权组织国际局
年份:
2009
代理人:
摘要：
Coumarin derivatives represented by general formula (I), their preparation methods, and their uses as angiogenesis inhibitors for the treatment of tumor and angio-retina diseases. This type of compounds is obtained by modification based on the structure of osthol. Vascular endothelial cell growth inhibiting experiments show that compounds of formula (I) have obvious EVC-304 cell multiplication inhibiting activity. Compared with combretastatin A-4 (CA4), the inhibiting activity of formula (I) is stronger and 1.5-4.0 times the activity of CA4.
