VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE
发明人:
HANS, WOLFGANG CHRISTIAN,STEIDLER, LOTHAR,REMAUT, ERIK RENE
申请号：
CA2377107
公开号：
CA2377107C
申请日:
2000.07.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to a micro-organism, preferably a bacterialstrain, preferably a non-pathogenic strain, preferably a non-invasive strain,preferably a food grade strain, preferably a gram-positive bacterial strain,delivering a trefoil peptide <；i>；in vivo<；/i>；. Preferably said trefoil peptideis TFF1. The present invention further relates to a method for the delivery oftrefoil peptide to the gastro-intestinal tract comprising the administrationof such a bacterial strain. The present invention also relates to apharmaceutical composition comprising a trefoil peptide delivering bacteriumas well as methods of treatment of acute gastro-intestinal inflammatorydiseases comprising administration of said transformed bacterial strains,particularly for treating acute colitis, including but not limited to acuteflare-ups of Crohn's disease and ulcerative colitis in humans, as well as fortreating gastro-intestinal disorders of a similar nature in other animalspecies.
