RÉGULATION PAR LIN28 DE LA BIOGENÈSE DE LET-7

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专利权人:

CHILDRENS MEDICAL CENTER CORPORATION;CHILDREN'S MEDICAL CENTER CORPORATION;DANA-FARBER CANCER INSTITUTE, INC.

发明人:

GREGORY, RICHARD,PISKOUNOVA, ELENA,ILIOPOULOS, DIMITRIOS

申请号：

EP12763967

公开号：

EP2688595A4

申请日:

2012.03.26

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present embodiments provide for compositions and methods that regulate microRNA-binding protein-mediated miRNA biogenesis； for example Lin28-mediated biogenesis of let-7； and in particular Lin28A-recruited 3' terminal uridylyl transferase (TUTase) uridylation of pre-let-7. A particular embodiment provides compositions and methods for screening for agents that inhibit TUTase-dependent Lin28A-mediated repression of let-7 miRNA.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/