Ling-Jie Gao,Piet André Maurits Maria Herdewijn,Steven Cesar Alfons De Jonghe,William John Watkins,Lee Shun Chong
申请号：
US12374242
公开号：
US08673929B2
申请日:
2007.07.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention provides the treatment of viral infections with a 4,6-disubstituted or 2,4,6-trisubstituted quinazoline derivative represented by the structural formula [(I)] wherein: R2 is selected from the group consisting of hydrogen, NR′R″ and C1-7 alkyl —A is selected from the group consisting of a bond, O, S(O)n, C1-7 alkylene, C2-7 alkenylene and C2-7 alkynylene R4 is selected from the group consisting of C1-7 alkyl, C2-7 alkenyl, C3-10cycloalkyl, C3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted alkyl and cycloalkyl-alkyl —Y is selected from the group consisting of a single bond, C1-7 alkylene, C2-7 alkenylene, and C2-7 alkynylene n is 0, 1 or 2 and R6 is selected from the group consisting of halogen, heteroaryl and aryl a pharmaceutically acceptable addition salt, a stereoisomer, a mono- or a di-Λ/-oxide, a solvate or a pro-drug thereof.
