Process for the preparation of anticholinergic tiotropium bromide as well as use of tropenol ester as starting material

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专利权人:

BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG.

发明人:

ROLF BAHNHOLZER,MANFRED GRAULICH,SVEN LUETTKE,ANDREAS MATHES,HELMUT MEISSNER,PETER SPECHT,WOLFGANG BROEDER

申请号：

BR0116444

公开号：

BRPI0116444B1

申请日:

2001.12.12

申请国别(地区):

BR

年份:

2015

代理人:

摘要：

Tiotropium bromide is produced from di-(2-thienyl)-glycolic acid tropenol ester in a two step process comprising oxidation and subsequent quaternisation. Production of tiotropium bromide (I) comprises oxidation of the di-(2-thienyl)-glycolic acid tropenol ester (II) and quaternisation of the resulting di-(2-thienyl)-glycolic acid scopine ester (III) with methyl bromide.

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