BANHOLZER ROLF,GRAULICH MANFRED,LUETTKE SVEN,MATHES ANDREAS,MEISSNER HELMUT,SPECHT PETER,BROEDER WOLFGANG
申请号：
HU0301457
公开号：
HU230320B1
申请日:
2001.12.12
申请国别(地区):
HU
年份:
2016
代理人:
摘要：
Tiotropium bromide is produced from di-(2-thienyl)-glycolic acid tropenol ester in a two step process comprising oxidation and subsequent quaternisation. Production of tiotropium bromide (I) comprises oxidation of the di-(2-thienyl)-glycolic acid tropenol ester (II) and quaternisation of the resulting di-(2-thienyl)-glycolic acid scopine ester (III) with methyl bromide.
