SUNG, JEAN C.,MANZANEDO, DIANA,PERRY, JASON M.,DEHAAN, WESLEY, H.,TRAUTMAN, BRIAN
申请号：
MX2015013845
公开号：
MX2015013845A
申请日:
2014.03.13
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The present invention relates to respirable dry powder comprising respirable dry particles that comprise sodium chloride, leucine, and tiotropium bromide, wherein the sodium chloride is about 60% to about 90%, the leucine is about 10% to about 40%, the tiotropium bromide is about 0.01% to about 0.5%, and optionally one or more additional therapeutic agents up to about 20%, wherein all percentages are weight percentages on a dry basis and all the components of the respirable dry particles amount to 100%. The invention also relates to respirable dry powders that contain respirable dry particles that comprise sodium chloride, leucine, and tiotropium bromide, wherein the sodium chloride is 67% to 84%, the leucine is 12% to 28%, the tiotropium bromide is about 0.01% to about 0.5%, and optionally one or more additional therapeutic agents up to about 20%, wherein all percentages are weight percentages on a dry basis and all the components of the respirable dry particles amount to 100%. The invention also relates to respirable dry powders that contain respirable dry particles that comprise about 79.5% to about 80.5% (w/w) sodium chloride, about 19.5% to about 20.5% (w/w) leucine, and about 0.01% to about 0.5% (w/w) tiotropium bromide, and methods for treating a subject using the respirable dry powders.La presente invención se refiere a polvo seco respirable que comprende partículas secas respirables que comprenden cloruro de sodio, leucina, y bromuro de tiotropio, en donde el cloruro de sodio es de aproximadamente 60% a aproximadamente 90%, el leucina es de aproximadamente 10% a aproximadamente 40%, el bromuro de tiotropio es de aproximadamente 0.01% a aproximadamente 0.5%, y opcionalmente uno o más agentes terapéuticos adicionales hasta aproximadamente 20%, en donde todos los porcentajes son porcentajes en peso sobre una base seca y todos los componentes de la cantidad de partículas secas respirables al 100%. La invención se refiere también a polvos secos respirables que c
