TAO, ZHI-FU,WANG, XILU,WENDT, MICHAEL D.,SOUERS, ANDREW J.,JUDD, ANDREW S.,KUNZER, AARON,SULLIVAN, GERARD
申请号：
PE2015001909
公开号：
PE20151555A1
申请日:
2014.02.21
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
REFERS TO COMPOUNDS: 4- (4 - {[2- (4-CHLOROPHENYL) -4,4-DIMETILCICLOHEX-1-EN-1-IL] METHYL} PIPERAZIN-1-IL) -N - [(4- {[(2R) -1,4-DIOXAN-2-ILMETIL] AMINO} -3-NITROFENIL) SULFONIL] -2- (1H-PIRROLO [2,3-b] PIRIDIN-5-ILOXI) BENZAMIDE； 4- (4 - {[2- (4-CHLOROPHENYL) -4,4-DIMETILCICLOHEX-1-EN-1-IL] METHYL} PIPERAZIN-1-IL) -N - [(3-NITRO-4 - {[ (1R) -1- (TETRAHIDRO-2H-PIRAN-4-IL) ETIL] AMINO} FENIL) SULFONIL] -2- (1H-PIRROLO [2,3-b] PIRIDIN-5-ILOXI) BENZAMIDE； AMONG OTHERS. THEY ALSO REFER TO COMPOSITIONS THAT CONTAIN THEM. SUCH COMPOUNDS INHIBIT THE ACTIVITY OF ANTIAPOPTOTIC PROTEINS Bcl-2 BEING USEFUL TO TREAT BLADDER CANCER, FOLICULAR LYMPHOMA, MELANOMASE REFIERE A LOS COMPUESTOS: 4-(4-{[2-(4-CLOROFENIL)-4,4-DIMETILCICLOHEX-1-EN-1-IL]METIL}PIPERAZIN-1-IL)-N-[(4-{[(2R)-1,4-DIOXAN-2-ILMETIL]AMINO}-3-NITROFENIL)SULFONIL]-2-(1H-PIRROLO[2,3-b]PIRIDIN-5-ILOXI)BENZAMIDA； 4-(4-{[2-(4-CLOROFENIL)-4,4-DIMETILCICLOHEX-1-EN-1-IL]METIL}PIPERAZIN-1-IL)-N-[(3-NITRO-4-{[(1R)-1-(TETRAHIDRO-2H-PIRAN-4-IL)ETIL]AMINO}FENIL)SULFONIL]-2-(1H-PIRROLO[2,3-b]PIRIDIN-5-ILOXI)BENZAMIDA； ENTRE OTROS. TAMBIEN SE REFIEREN A COMPOSICIONES QUE LOS CONTIENEN. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LAS PROTEINAS ANTIAPOPTOTICAS Bcl-2 SIENDO UTILES PARA TRATAR CANCER DE VEJIGA, LINFOMA FOLICULAR, MELANOMA
