TAO, Zhi-Fu,WANG, Xilu,WENDT, Michael D.,SOUERS, Andrew J.,JUDD, Andrew S.,KUNZER, Aaron,SULLIVAN, Gerard
申请号：
PE2019001832
公开号：
PE20191555A1
申请日:
2014.02.21
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
[4 - [4 -]], [4 - [4 - [4 - [4 -]]]]]] 1. Ethyl cyclohexane-1-en-1-il] methyl - (piperazin-1-il) - N - [(3-nitro-4 - [(5S), (8) (s) - 1-oxaespiro [4.5] dec-8-ilmet] amine - (phenyl) sulfuric acid] - 2 - (1H pirrolo [2, 3-B] piridin-5-iloxi) benzamida； and others. He also mentioned a pharmaceutical composer These compounds inhibit the activity of Bcl-2 anti pop proteins because they are effective tools for cancer treatment.REFERIDO A COMPUESTOS SELECCIONADOS COMO: 4-(4-{[2-(4-CLOROFENIL)-4,4-DIMETILCICLOHEX-1-EN-1-IL]METIL}PIPERAZIN-1-IL)-N-[(3-NITRO-4-{[(1S)-1-(TETRAHIDRO-2H-PIRAN-4-IL)ETIL]AMINO}FENIL)SULFONIL]-2-(1H-PIRROLO[2,3-b]PIRIDIN-5-ILOXI)BENZAMIDA； 4-(4-{[2-(4-CLOROFENIL)-4,4-DIMETILCICLOHEX-1-EN-1-IL]METIL}PIPERAZIN-1-IL)-N-[(3-NITRO-4-{[(5s,8s)-1-OXAESPIRO[4.5]DEC-8-ILMETIL]AMINO}FENIL)SULFONIL]-2-(1H-PIRROLO[2,3-b]PIRIDIN-5-ILOXI)BENZAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LAS PROTEINAS ANTIAPOPTOTICAS Bcl-2 SIENDO UTILES PARA TRATAR CANCER
