Novel aryl, heteroaryl, and non-aromatic heterocyle substituted tetrahydroisoquinolines are described in the present invention. These compounds are used in the treatment of various neurological and physiological disorders. Methods of making these compounds are also described in the present invention.在本發明中描述了新的芳基、雜芳基和非芳族雜環取代的四氫異喹啉。這些化合物用於治療各種神經學和生理學病症。在本發明中還描述了製備這些化合物的方法。