The present invention relates to compounds of formula (I): wherein Q is selected from O or S； R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted； and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted.The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.本發明係關於式(I)化合物： 其中Q係選自O或S；R1係包含至少一個環氮原子之非芳族雜環狀基團，其中R1藉由環碳原子連接至磺醯基脲基團之硫原子，且其中R1可視情況係取代的；且R2係在α位取代之環狀基團，其中R2可視情況係進一步取代的。本發明進一步關於此類化合物之鹽、溶劑合物、及前藥，包含此類化合物之醫藥組成物，及此類化合物在治療及預防醫學病症及疾病中之用途，最尤其是藉由抑制NLRP3在治療及預防醫學病症及疾病中之用途。
