PROBLEM TO BE SOLVED: To develop a safe and stable novel material for promoting NO production, and provide such a composition that can utilize the same for industrial applications.SOLUTION: The present invention provides an NO production promoter in vascular endothelial cells that comprises, as an effective ingredient, an aqueous component of defatted lees of a seed of Camellia japonica belonging to the genus Camellia of the family Theaceae and/or the rhizome of plants belonging to the genus Astilbe such as Astilbe thunbergii, and an oral composition such as food and drink containing the NO production promoter.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】NO産生を促進するための、安全かつ安定な新規素材を開発するとともに、これを産業上有効活用できる態様の組成物を提供する。【解決手段】ツバキ科ツバキ属に属するツバキの種子の脱脂粕の水性成分及び/又はアカショウマ等のチダケサシ属に属する植物の根茎を有効成分として含有してなることを特徴とする血管内皮細胞でのNO産生促進剤、該NO産生促進剤を含有してなる飲食品等の経口組成物。【選択図】なし。