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Process for the production of brevikollin-base from Carex brevicollis D.C.
专利权人:
INSTITUTUL DE CHIMIE AL ACADEMIEI DE STIINTE A MOLDOVEI
发明人:
MAKAEV FLYUR,SHEPELI FELIX,SHEPELI DIANA,ZVEAGHINTEVA MARINA,SEPELI OXANA,SUCMAN NATALIA,BOLDESCU VEACESLAV,DUCA GHEORGHE,MACAEV FLIUR,&SCEDILEPELI FELIX,&SCEDILEPELI DIANA,ZVEAGHIN&TCEDILEVA MARINA,&
申请号:
MD20110013
公开号:
MD4146C1
申请日:
2011.02.04
申请国别(地区):
MD
年份:
2012
代理人:
摘要:
The invention relates to pharmaceutical industry, in particular to the production of brevikollin-base from Carex brevicollis D.C.The process, according to the invention, comprises drying of the plant material from Carex brevicollis D.C. plants to a humidity of at most 5…7% its subsequent milling in a hammer mill with a holes sizes of 5x25 mm treatment of the milled plant material with 1% sulfuric acid solution at the temperature of 80…85°C and the pressure of 16·103...20·103 Pa extraction in the steady-state regime in an extraction system, formed of at least three capacities in the shape of a funnel connected in series and placed vertically, with 1% sulfuric acid solution at the temperature of 80…85°C during 48 hours combination of extracts neutralization and alkalization of the acid extract up to pH 8…9 extraction with organic solvents with intensive stirring for 3…5 min concentration of the extract up to dry residue treatment of the dry residue with acetone in the ratio of 1:3 respectively boiling of suspension with reverse agitation for 10…15 min cooling to -5…0°C filtration washing with cold acetone and drying.Invenţia se referă la industria farmaceutică, în particular la obţinerea brevicolinei-bază din Carex brevicollis D.C.Procedeul, conform invenţiei, include uscarea masei vegetale din plante de Carex brevicollis D.C. până la umiditatea de cel mult 5…7% mărunţirea ulterioară a acesteia într-un concasor cu ciocane cu dimensiunile orificiilor de 5x25 mm tratarea masei vegetale mărunţite cu soluţie de acid sulfuric de 1% la temperatura de 80...85°C şi presiunea de 16·103...20·103 Pa extragerea în regim staţionar într-un sistem de extragere, format din cel puţin trei capacităţi de tip pâlnie unite consecutiv şi amplasate vertical, cu o soluţie de acid sulfuric de 1% la temperatura de 80...85°C timp de 24...48 ore unirea extractelor neutralizarea şi alcalinizarea extractului acid până la pH 8…9 extragerea cu solvenţi organici cu agitarea intensă timp de 3…5 min co
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