INHIBITION OF HSV-1-ASSOCIATED CORNEAL NEOVASCULARIZATION USING INHIBITORS OF CYCLIN-DEPENDENT KINASE 9

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专利权人:

发明人:

Harris E MCFERRIN

申请号：

US15329964

公开号：

US20180200279A1

申请日:

2015.07.30

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Provided are methods of preventing and/or treating herpes simplex virus-1 (HSV-1)-associated ocular neovascularization comprising administering a cyclin-dependent kinase (CDK) inhibitor. Preferably a CDK9 inhibitor, such as flavopiridol or dichlorobenzimidazole-1-β-D-ribofuranoside (DRB), is administered to prevent and/or treat HSV-1-associated ocular neovascularization. Additionally, methods of inhibiting angiogenesis and HSV-1 replication comprising the use of a cyclin-dependent kinase inhibitor are provided.

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