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2,1,3-BENZOXADIAZOL DERIVATIVES FOR THE INHIBITION OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION
专利权人:
发明人:
申请号:
EP10719756.8
公开号:
EP2427442A1
申请日:
2010.05.07
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
A 2,1,3-benzoxadiazole compound as a medicament according to the invention is one of the following compounds: 4-[(4-methoxybenzyl)thio]-7-nitro-2,1,3-benzoxadiazole, 2-[(7-nitro-2,1,3-benzoxadiazol-4- yl)thio]ethyl 4-methoxybenzene-1-sulfonate, 4-[(4-methylphenyl)thio]-7-nitro-2,1,3-benzoxadiazole, 4-[(2,4-dichlorophenyl)thio]-7-nitro-2,1,3-benzoxadiazole, 2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)thio]ethan-1-ol, 4-[(4-methylbenzyl)thio]-7-nitro-2,1,3-benzoxadiazole, 4-[(4-fluorophenyl)thio]-7-nitro-2,1,3- benzoxadiazole, 4-[(3-chlorophenyl)-thio]-7-nitro-2,1,3-benzoxadiazole, 2-[(7-nitro-2,1,3-benzoxadiazol-4- yl)thio]ethyl-4-methoxy-benzoate, 5-[4-(tert-butyl)-1,3-thiazol-2-yl]-2,1,3-benzoxadiazole, N-benzyl-4-nitro-2,1,3-benzoxadiazol-5-amine, 4-nitro-7-(phenylmethylsulfanyl)-2,1,3-benzoxadiazole, 4-nitro-7-(phenylmethylsulfonyl)-2,1,3-benzoxadiazole, 2-(hydroxymethyl)-5-[6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)sulfanyl]purin-9-yl]oxolane-3,4-diole, or 2-[2-amino-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)sulfanyl]purin-9-yl]-5-(hydroxymethyl) oxolane-3,4-diol or a physiologically tolerable salt, solvate, or physiologically functional derivative thereof. Said compounds are particularly advantageous for treating and/or preventing influenza type A and/or influenza type B infections in humans, mammals and/or birds, and for treating and/or preventing respiratory syncytial virus infections in humans, mammals and/or birds.Un composé de 2,1,3-benzoxadiazole en tant que médicament selon la présente invention est lun des composés suivants : le 4-[(4-méthoxybenzyle) thio]-7-nitro-2,1,3-benzoxadiazole, le 4-méthoxybenzène-1-sulfonate de 2-[(7-nitro-2,1,3-benzoxadiazol-4-yle) thio] éthyle, le 4-[(4-méthylphényle) thio]-7-nitro-2,1,3-benzoxadiazole, le 4-[(2,4-dichlorophényle) thio]-7-nitro-2,1,3-benzoxadiazole, le 2-[(7-nitro-2,1,3-benzoxadiazol-4-yle) thio] éthan-1-ol, le 4-[(4-méthylbenzyle) thio]-7-nitro-2,1,3-benzoxadiazole, le 4-[(4-fluorophényle) thio]-7-nitro-2,1,3-benzoxadiazole,
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