BISCHOFF, FRANCOIS PAUL,必斯克夫 法兰寇斯,必斯克夫 法蘭寇斯,GIJSEN, HENRICUS JACOBUS MARIA,金森 哈利克斯,金森 哈利克斯,PIETERS, SERGE MARIA ALOYSIUS,皮特斯 沙吉,皮特斯 沙吉,MINNE, GARRETT BERLOND,麦尼 葛雷特,麥尼 葛雷特
申请号：
TW099114456
公开号：
TWI461419B
申请日:
2010.05.06
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I)wherein R1, R2, R3, R4, Y, A1, A2, A3, A4, X1, X2, X3and Het1have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.本發明係關於式(I)之新穎經取代的吲唑及氮雜-吲唑衍生物類其中R1、R2、R3、R4、Y、A1、A2、A3、A4、X1、X2、X3及Het1具有在申請專利範圍中定義之意義。根據本發明之化合物可以作為伽瑪分泌酶調節劑。本發明還關於製備此新穎化合物之方法、包含該化合物作為有效成份之醫藥組成物以及該化合物作為藥劑之用途。
