Felicity Meredith Dunlop;Louis Jerry Fabri;Manuel Baca;Douglas James Hilton;Nicos A. Nicola;Andrew Donald Nash
发明人:
Felicity Meredith Dunlop,Manuel Baca,Andrew Donald Nash,Louis Jerry Fabri,Douglas James Hilton,Nicos A. Nicola
申请号：
US12828589
公开号：
US08221755B2
申请日:
2010.07.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.
