DUNLOP, FELICITY MEREDITH,BACA, MANUEL,NASH, ANDREW DONALD,FABRI, LOUIS JERRY,HILTON, DOUGLAS JAMES,NICOLA, NICOS A.
申请号：
CA2480059
公开号：
CA2480059C
申请日:
2003.03.21
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates generally to antibodies that bind to theInterleukin-13 receptor .alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13receptor-mediated signaling by IL-13 and/or IL-4. More particularly, thepresent invention provides humanized or human antibodies to mammalian and inparticular IL-13R.alpha.1. These antibodies have uses in the treatment orprevention of IL-13- and/or IL-4-mediated diseases or conditions. The presentinvention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subjectantibodies. The present invention further provides an assay system useful foridentifying antibodies or other agents which modulate IL-13 and/or IL-4signaling through an IL-13 receptor complex. Accordingly, a method ofscreening for modulators of IL-13R.alpha.1/ligand interaction is also provided.
