NASH, ANDREW DONALD,BACA, MANUEL,FABRI, LOUIS JERRY,ZALLER, DENNIS,STROHL, WILLIAM R.,AN, ZHIQIANG
申请号：
CA2666682
公开号：
CA2666682C
申请日:
2007.10.19
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Antibody antagonists of human interleukin-13 receptor alpha 1 which bind to hIL-13R.alpha.l through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13 are disclosed herein. These antibodies have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing hIL-13R.alpha.l- mediated activities are also disclosed.
