JAROSKOVA, LIBUSE,LINDERS, JOANNES THEODORUS MARIA,VAN DER VEKEN, LOUIS JOZEF ELISABETH,WILLEMSENS, GUSTAAF HENRI MARIA,BISCHOFF, FRANCOIS PAUL
申请号：
CA2576839
公开号：
CA2576839C
申请日:
2005.08.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The N-oxide forms, the pharmaceutically acceptable addition salts and thestereochemically isomeric forms thereof, wherein n is 1, 2, 3, or 4； Zrepresents O, S, NR6, SO or SO2； R1 represent hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted with halo, R2 represents hydrogen, C1-4alkyl, orC1-4alkyloxy-； R3 represents hydrogen, C1-4alkyl, C1-4alkyloxy- or R3 combinedwith R2 form together a divalent radical selected from the group consisting of-O-CH2- (a), -NR7-CH2- (b), -(CR8R9)m- (c) and -CR10= (d) wherein m represents1 or 2 and R7, R8, R9 and R10 are each independently selected from hydrogen orC1-4alkyl； R4 represents hydrogen, halo, hydroxy, cyano, amino, NR11R12, C1-4alkyloxy- optionally substituted with one or where possible two or threesubstituents selected from hydroxy and halo or R4 represents C1-4alkyloptionally substituted with one or where possible two or three substituentsselected from hydroxy and halo； R5 represents hydrogen, halo, cyano, amino,phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR13R14 or C1-4alkylsubstituted with one or more substituents selected from hydroxycarbonyl,phenyl, C1-4alkyloxy or NR15R16； R6 represents hydrogen； R11 and R12 eachindependently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl-； R13 andR14 each independently represent hydrogen, C1-4 alkyl or C1-4 alkylcarbonyl-；R15 and R16 each independently represent hydrogen, C1-4 alkyl or C1-4alkylcarbonyl-； R17 and R18 each independently represent hydrogen, C1-4 alkylor C1-4 alkylcarbonyl-.
