There is the two-dimensional material of multiple opening thereon, be based particularly on the material of Graphene, the encapsulation object of many kinds of substance can be formed and be introduced into environment, particularly biotic environment (inner or in vitro).The substance release that one or more select can be entered described environment, one or more materials selected from described environment can enter described encapsulation object, one or more materials selected from described environment can be stoped to enter described encapsulation object, one or more materials selected can be retained in described encapsulation object, or above combination.Described encapsulation object can such as allow for perception response paradigm.Described encapsulation object for example, can provide immunity isolation by its interior material (such as living cells) retained.