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COMPOSITIONS AND METHODS FOR IN VITRO ASSAYS OF FIBRIN ACTIVITY
专利权人:
发明人:
申请号:
EP15735284.0
公开号:
EP3091996A1
申请日:
2015.01.09
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention provides compositions exhibiting in vivo activity of fibrin in an in vitro setting, in vitro assays comprising such compositions, methods of producing such compositions, and methods of using such compositions and assays. The compositions of the invention include molecules with the biochemical properties of 1) high affinity binding to fibrin receptors and 2) activation of cell-signaling systems comparable to that observed in vivo by fibrin. The fibrin compositions of the invention are compatible both in biochemical assays and cell-based assays, and thus useful for in vitro assays for screening of test agents that modulate cell activation and/or signaling pathways mediated by fibrin or associated with fibrin activity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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