The present invention is directed to preparing medicaments, nutritional supplements, or food supplements that can improve the various problems associated with cystic ovarian disease observed in cattle or increase 17- estradiol levels Of a combination of 25-hydroxy vitamin D 3 ("25-OH D 3") and an antioxidant / anti-inflammatory agent (ascorbic acid, vitamin E, and at least one carotenoid). Also provided is a feed, as well as a premix containing 25-OH D3 and an antioxidant / anti-inflammatory agent and a premix.Selection drawing None