MITCHELL, MICHAEL L.,ROETHLE, PAUL A.,XU, LIANHONG,YANG, HONG,MCFADDEN, RYAN,BABAOGLU, KERIM
申请号：
PE0023472013
公开号：
PE10662014A1
申请日:
2012.04.20
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relating to compounds of formula (i) where s or N: G1, G2 is n, S, among others The dotted line connected to G1 is a Union simple or double The dotted line connected to G2 is a Union simple or double The Wavy Line R5 is connected to a single or Double Bond R5 is, or Halo, Nitro, cyano, Tre r1 is A1A A1A or r1b is Halo, where, among others, r1b is aryl, heteroaryl, Nitro, cyano,Among others R2 is 2a or R2B, where 2a is Halo, among others, is - R2B (C2 - C6) alquinil - (C1 - C6) haloalquilo, Nitro, cyano, among others R3 is R3A r3b is or where R3A (C1 - C6) alkyl (C1 - C6) haloalquilo, alquenilo (C2 - C6), among others, r3b is aryl, heteroaryl, heterocycle, among others r3\ufffdes r3a\ufffd or R3b\ufffd, where r3a\ufffd is H, r3b\ufffd is H, alkyl or (C1 - C6) - or (C1 - C6) alkyl R4 is R4A or r4b,Where R4A is aryl, Heterocyclic and heteroaryl substituted, Optionally, r4b is (C1 - C6) alkyl (C2 - C6) alquenilo (C2 - C6) alquinilo optionally substituted, among others. Also referred to a Pharmaceutical composition. This Compound is useful for the prophylactic Treatment of HIV infection in a MammalREFERIDO A COMPUESTOS DE FORMULA (I) DONDE: G1 ES S O N G2 ES N, S, ENTRE OTROS LA LINEA PUNTEADA CONECTADA A G1 ES UNA UNION SIMPLE O DOBLE LA LINEA PUNTEADA CONECTADA A G2 ES UNA UNION DOBLE O SIMPLE LA LINEA ONDULADA CONECTADA A R5 ES UNA UNION SIMPLE O DOBLE R5 ES O, HALO, NITRO, CIANO, ENTRE OTROS R1 ES R1a O R1b, DONDE R1a ES HALO, ENTRE OTROS, R1b ES ARILO, HETEROARILO, NITRO, CIANO, ENTRE OTROS R2 ES R2a O R2b, DONDE R2a ES HALO, ENTRE OTROS, R2b ES -(C2-C6)ALQUINIL-(C1-C6)HALOALQUILO, NITRO, CIANO, ENTRE OTROS R3 ES R3a O R3b, DONDE R3a ES (C1-C6)ALQUILO, (C1-C6)HALOALQUILO, (C2-C6)ALQUENILO, ENTRE OTROS R3b ES ARILO, HETEROARILO, HETEROCICLO, ENTRE OTROS R3�ES R3a� O R3b�, DONDE R3a� ES H, R3b� ES H, (C1- C6)ALQUILO O -O(C1-C6) ALQUILO R4 ES R4a O R4b, DONDE R4a ES ARILO, HETEROCICLO Y HETEROARILO, OPCIONALMENTE SUSTITUIDOS, R4b ES (C1-C6)ALQUILO, (C2-C6)ALQUENILO, (C
