BRIDGED RING COMPOUNDS AS HCV INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF农业专利-农业专业知识服务系统

发明人:: ZHANG, YING-JUN,张英俊,張英俊,ZHANG, JIANCUN,张健存,張健存,XIE, HONG-MING,谢洪明,謝洪明,REN, QING-YUN,任青云,任青雲,HU, BO-LIN,胡柏林,胡柏林,LI, SHI-FENG,李石凤,李石鳳,WU, XI-WEI,巫锡伟,巫錫偉,TANG, CHANG-HUA,唐昌华,唐昌華,WANG, CHENG-LIN,汪成林,汪成林,F

摘要：: Provided herein is a compound of formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof, which can also be used for treating HCV infection or a HCV disorder.本發明提供了作為丙型肝炎抑制劑的橋環化合物及其藥物組合物和用途。所述化合物為式(I)所示的化合物或式(I)所示化合物的立體異構體、幾何異構體、互變異構體、氮氧化物、水合物、溶劑化物、代謝產物、藥學上可接受的鹽或前藥。此外,本發明還提供了包含所述化合物的藥物組合物,所述化合物和所述藥物組合物用於抑制HCV複製過程和抑制HCV病毒蛋白功能的至少之一的用途,以及所述化合物和所述藥物組合物用於預防、處理、治療或減輕患者的HCV感染或丙型肝炎疾病的用途。