作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用农业专利-农业专业知识服务系统

发明人:: 张英俊,張英俊,张健存,張健存,谢洪明,謝洪明,任青云,任青雲,巫锡伟,巫錫偉,罗慧超,羅慧超,付长萍,付長萍,胡柏林,李石凤,李石鳳,唐昌华,唐昌華,雷勇,于全兴,于全興,方清洪,汪成林,ZHANG, YING-JUN,ZHANG, JIAN-CUN,XIE, HONG-MING,REN, QING-YUN,WU, XI-WEI,LUO, HUI-CHAO,FU, CHANG-PING,HU, BO-LIN,LI, SHI-FENG,TAN

摘要：: A compound of formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof is provided, which can be used for treating HCV infection or a HCV disorder. Also a pharmaceutical composition comprising the compound and the use of the compound and the pharmaceutical composition thereof are provided, which can also be used for treating HCV infection or a HCV disorder.本發明提供一些如式(I)所示的螺環化合物或其立體異構體，幾何異構體，互變異構體，氮氧化物，水合物，溶劑化物，代謝產物，藥學上可接受的鹽或前藥，用於治療丙型肝炎病毒(HCV)感染或丙型肝炎疾病。本發明還公開了含有這樣的化合物的藥物組合物和本發明化合物或其藥物組合物在製備用於治療HCV感染或丙型肝炎疾病的藥物中的用途。