DENG, Yonghong,PLAMONDON, Louis,SUN, Cuixiang,XIAO, Xiao-Yi,ZHOU, Jingye,SUTCLIFFE, Joyce,RONN, Magnus
申请号：
ES10750214
公开号：
ES2654987T3
申请日:
2010.08.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Structural Formula I: Formula ** ** or a pharmaceutically acceptable salt thereof, wherein: X is -CF3 Y is selected from hydrogen, -C (C1-C4) -N (R2) (R3), -CH> = N-OR2, -C (O) -N (R2) (R4), -NO2, -COOH, -OH, - N> = CH-N (R2) (R3), -N (R2) (R3), -N (RF) -C (O) - [C (R5a) (R5b)] 1-4- N (R2) (R3), -N (RF) -C (O) (C1-C6), -N (RF) -C (O) - heterocyclyl, -N (RF) -C (O) - carbocyclyl, -N (RF) -S (O) m (C1-C4) -N (R2) (R3), -N (RF) -S (O) mN (R2) (R4) and - N ( RF) -S (O) m-alkylene -carbociclilo (C1-C4), wherein: each R2 is independently selected from hydrogen and (C1-C3) each R3 is independently selected from hydrogen, (C1-C6) -O-alkyl (C1-C6) -alkylene (C0-C6) - carbocyclyl, -C (C0-C6) -heterocyclyl, -S (O) m-alkyl (C1-C6) -S (O) m-carbocyclyl and -S (O) m-heterocyclyl and each R4 is independently selected from hydrogen, (C1-C6) -O-alkyl (C1-C6) -alkylene (C0-C6) - carbocyclyl and -C (C0-C6) -heterocyclyl or R2 and R3 taken together with the nitrogen atom to which they are attached form a heterocyclyl, wherein heterocyclyl optionally comprises 1 to 4 additional heteroatoms independently selected from N, S and O each R5a and each R5b are independently selected from hydrogen, (C1-C6) alkyl, carbocyclyl, heterocyclyl or a residue of amino acid side chain of natural origin, or R5a and R5b taken together with the carbon atom to which they are attached form a carbocyclyl saturated 3-7 membered heterocyclyl or 4-7 membered saturated, wherein the saturated heterocyclyl consisting of R5a and R5b optionally comprises one or two additional heteroatoms independently selected from N, S and O, RF is hydrogen or (C1 -C3) each m is 1 or 2, wherein: each carbocyclyl or heterocyclyl is optionally independently substituted with one or more substituents independently selected from chloro, fluoro, (C1-C4), -OH, -O- (C1-C4) , (C1-C4) alkyl substituted with fluorine, -C (O) (C1-C4), -C (O) - ((C1-C4) fluoro-substituted) and -N (RG) (RG) each RG is hydrogen or (C1-C4) -alkyl, wh
