National University of Singapore;Agency for Science, Technology and Research
发明人:
GOH, Cho Hong James,TEH, Kok Hiong Thomas,SHI, Pujiang,HUI, Hoi Po James,LI, Jun
申请号：
EP20140826226
公开号：
EP3021791(B1)
申请日:
2014.07.21
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material. The present invention is also directed to a method for the manufacturing of such augmentation devices, a method for fixation of the thus fabricated tissue interface augmentation devices onto ligament or tendon grafts, a method for applying such devices for ligament and/or te
