The United States of America; as represented by the Secretary;Department of Health and Human Service
发明人:
Kenichi Hanada,Qiong J. Wang,James C. Yang,Zhiya Yu
申请号：
US16586310
公开号：
US20200102383A1
申请日:
2019.09.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG470-478. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
