T cell receptor that recognizes MHC class II restricted MAGE-A3

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专利权人:

アメリカ合衆国

发明人:

ロビンズ、ポール エフ．,ローゼンバーグ、スティーヴン エイ．,ヤオ、シン,ロビンズ、ポール エフ.,ローゼンバーグ、スティーヴン エイ.

申请号：

JP2015532065

公开号：

JP6461796B2

申请日:

2013.09.13

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The invention provides an isolated or purified T-cell receptor (TCR) having antigenic specificity for MHC Class II-restricted MAGE-A3. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a mammal are further provided by the invention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/