The United States of America;as represented by the Secretary;Department of Health and Human Services
发明人:
Paul F. Robbins,Steven A. Rosenberg,Xin Yao
申请号：
US15848344
公开号：
US20180127479A1
申请日:
2017.12.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides an isolated or purified T-cell receptor (TCR) having antigenic specificity for MHC Class II-restricted MAGE-A3. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a mammal are further provided by the invention.
