Embodiments of the present disclosure present systems, methods and devices relate to regulating drug absorption in a body of a patient, including delivering a dose of long-acting drug at a delivery site of a patient, applying a treatment to a treatment area surrounding and including the delivery site. A substantial portion of the drug may reside in tissue adjacent the treatment area for an extended period of time and may include a drug depot. The treatment may be configured to modify the level of at least one property of at least a portion of the treatment area. The absorption rate of the long-acting drag from the drug depot changes according to the level of the property.
